In Florenza, the players are the heads of the most powerful families in Florenza during the Renaissance period. The goal of the game is to become the most famous patron of the arts by hiring the most famous artists of the period and financing their works.

Each player can commission artworks in his own district, the Cathedral, or in the civic buildings of the city. Each artwork requires money and resources to complete. To earn the needed money and resources, the players send their workers to labor in various workshops, possibly even in their opponents' districts. Additional workers can be earned by offering charity to the church.