It's senior year at the Horribilorum Sorcery Academy for Witty Witches and Wizards. All the hard work and studying comes down to this: the final exam! Under the helpful tutelage of the Headmaster, players have learned how to handle volatile ingredients and turn them into fantastical potions!

In Potion Explosion 2nd Edition, players take on the role of students trying to pass their final exam for the year. To do this, they'll be creating potions by pulling marbles from the new plastic dispenser. These represent ingredients in the various potion recipes. When a marble is taken, the rest slide down the ramp. If two same-color marbles touch, an explosion happens and the player can take those marbles, too! More explosions means more marbles and faster potion-making. Each completed potion also grants a special ability when drunk. At the end of the game, the player that scores the most points is deemed head of the class and graduates with top honors.