Ghostbusters?: The Board Game is a game for 1-4 players, ages 15 and up. Players choose one of the four Ghostbusters character figures (Peter Venkman, Egon Spengler, Winston Zeddemore and Ray Stantz) and then select from one of the game's pre-written scenarios, beginning a game session that lasts from 30 minutes to 2 hours, depending on the chosen scenario(s) and degree of difficulty. Each of the Ghostbusters has unique traits and talents that can assist the entire team, with highly cooperative gameplay. As players gain experience from banishing spirits, the Ghostbusters level up, gaining new abilities that help them take on greater challenges. The team can also hop in the Ecto-1, the Ghostbusters' converted ambulance, to help them quickly move through the city.

Ghostbusters?: The Board Game comes with plastic figures of the four Ghostbusters as well as Slimer, Stay Puft Marshmallow Man, Indulnas and numerous Galloping Ghouls, Gruesome Twosomes and Boogaloo. All figurines are based on the artwork and designs of Dan Schoening, the artist of IDW's Ghostbusters? comic book. The game will come with over 40 figures, with the opportunity to purchase add-ons and exclusive figures. The board itself is made of double-sided modular pieces illustrated by Robb Mommaerts, increasing the replayability for scenarios and customization.