Destination X is a game of one-against-many: One player takes the moderator role as a spy on the run, while the remaining players are detectives who must cooperate and use their deductive skills and geographical knowledge to track down the spy and identify their secret destination.
At the beginning of each round, six destination cards are placed face up on the table. The spy secretly chooses one of the destinations, and flips to the chosen country's page in the handbook. Each detective is given three informant cards, and in turn each detective must play an informant to get information about the spy's secret destination. The spy must find the relevant information in the handbook and answer truthfully. The informants may provide information on various aspects such as population, industry, religion, history, economy, and so on. After a detective has played an informant, the detective must also eliminate one of the destinations on the table.
At any time, the detectives can decide to guess on the spy's destination. If they guess correctly, the detectives win the round; otherwise the spy wins. The spy also wins if the detectives run out of informant cards, so the detectives must manage their resources well and not spend too much time or else the spy will manage to get away. The first side to win three rounds wins the game.
No prior geographic knowledge is needed to play, but having some insight might still help you in deducing the spy's destination. Since Destination X is a team-based game, it can be played in groups of any number of players.